Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?
- 1 November 1991
- journal article
- review article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 47 (3) , 201-207
- https://doi.org/10.1002/jcb.240470303
Abstract
Basic fibroblast growth factor (bFGF), a potent angiogenesis inducer, lacks a signal sequence. Therefore, it has been proposed that bFGF is primarily released from dead or damaged cells. Other proteins devoid of secretion signals, interleukin 1β (IL‐1β) and the muscle lectin L‐14, have been shown to be released via exocytosis, a novel secretion pathway independent of the “classic” endoplasmic reticulum‐Golgi route. In the light of these findings and of our own recent results, we discuss evidence that bFGF can be released from single, uninjured cells and mediate functions is an autocrine manner. As is the case for IL‐1β and L‐14, externalization of bFGF may occur via exocytosis, a pathway utilized during development and differentiation.Keywords
This publication has 83 references indexed in Scilit:
- Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active formJournal of Cellular Physiology, 1989
- The sequence of human parathymosin deduced from a cloned human kidney cDNABiochemical and Biophysical Research Communications, 1989
- The fibroblast growth factor family: Structural and biological propertiesProgress in Growth Factor Research, 1989
- An in vivo model for study of the angiogenic effects of basic fibroblast growth factorBiochemical and Biophysical Research Communications, 1987
- Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growthNature, 1987
- Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.The Journal of cell biology, 1986
- Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblastsBiochemistry, 1986
- Low temperature-induced cell surface membrane vesicle shedding is associated with DNA fragmentationExperimental Cell Research, 1985
- FIBROBLAST GROWTH FACTOR AND THE CONTROL OF VERTEBRATE REGENERATION AND REPAIR*Annals of the New York Academy of Sciences, 1980
- Peripheral hyaline blebs (podosomes) of macrophagesThe Journal of cell biology, 1977