T1Wh, a promising mouse strain with chromosomal markers for cleft palate research

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Abstract
Attainment of the horizontal position by the secondary palatal shelves and fusion in relationship to morphological and chronological ages in TlWh, an albino strain of mice homozygous for a 5; 19 Robertsonian translocation, was found to be late and slow in comparison to other strains previously investigated. Spontaneous and cortisone‐induced cleft palate frequencies of 3.5% and 100% respectively, were found in this strain. Its slow and late palatal closure, high susceptibility to cortisone, obvious marker chromosomes, and good breeding performance promise to make TlWh a useful strain for cleft palate research.