Antascomicins A, B, C, D and E. Novel FKBP12 Binding Compounds from a Micromonospora Strain.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (3) , 230-233
- https://doi.org/10.7164/antibiotics.49.230
Abstract
5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.Keywords
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