Quantitative Studies on Anaphylaxis in Guinea-Pigs Passively Sensitized with Homologous Antibody

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Abstract
The course of anaphylaxis has been studied in guinea pigs passively sensitized by the injection of guinea-pig antibody to egg albumin. A variety of conditions were used for sensitization and for each condition the effect of an anti-histamine (mepyramine) was measured. Reduction in the amount of antiserum used led to a corresponding reduction in the severity of anaphylaxis but little change was found when the amount of antigen was altered over a 50-fold range. A considerable proportion of the anaphylactic response was resistant to anti-histamine treatment. A small part of the antibody was heat-stable but most of it was persistent for at least 10 days. β-adrenergic blockade increased the anaphylactic response and animals so treated were refractory to anti-histamine treatment.

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