Substance P and 5-HT in granules isolated from an intestinal argentaffin carcinoid
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Histochemistry and Cell Biology
- Vol. 52 (3) , 217-222
- https://doi.org/10.1007/bf00495858
Abstract
Intestinal argentaffin carcinoids, thought to originate from enterochromaffin cells, occasionally contain large amounts of substance P-like immunoreactivity in addition to 5-HT. The cytoplasmic granules of one such tumour were isolated. The granules, which in the electron microscope were shown to be argentaffin, contained both substance P-like immunoreactivity and 5-HT. The results support the view that substance P is localized in a population of enterochromaffin cells where it is stored in the cytoplasmic granules together with 5-HT.Keywords
This publication has 11 references indexed in Scilit:
- Enterochromaffin cells as the endocrine source of gastrointestinal Substance PHistochemistry and Cell Biology, 1976
- Presence of Substance P‐Like Immunoreactivity in Plasma from Man and DogActa Physiologica Scandinavica, 1975
- Localization of substance P-like immunoreactivity in mouse gutHistochemistry and Cell Biology, 1975
- Immunocytochemical localization of substance P in mammalian intestineHistochemistry and Cell Biology, 1975
- Diethylpyrocarbonate, a vapour-phase fixative for immunofluorescence studies on polypeptide hormonesJournal of Molecular Histology, 1974
- Occurrence and function of amines in endocrine cells producing polypeptide hormones.1973
- Electron microscopic classification of amine-producing endocrine cells by selective staining of ultra-thin sectionsHistochemistry and Cell Biology, 1971
- CONTRIBUTION TO THE CYTOSPECTROFLUOROMETRIC MEASUREMENT OF 5-HYDROXYTRYPTAMINE IN ENTEROCHROMAFFIN CELLSJournal of Histochemistry & Cytochemistry, 1969
- A MODIFICATION OF THE MASSON-HAMPERL METHOD FOR STAINING OF ARGENTAFFIN CELLS.1964
- STUDIES ON ANTIBODY PRODUCTIONThe Journal of Experimental Medicine, 1955