Simvastatin Normalizes Autonomic Neural Control in Experimental Heart Failure
- 20 May 2003
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 107 (19) , 2493-2498
- https://doi.org/10.1161/01.cir.0000065606.63163.b9
Abstract
Background— HMG-CoA reductase inhibitors (statins) have been shown to beneficially affect outcomes in chronic heart failure (CHF). We hypothesized that statins exert effects on autonomic function, as assessed by plasma norepinephrine levels, direct recordings of renal sympathetic nerve activity (RSNA), and baroreflex function.Keywords
This publication has 27 references indexed in Scilit:
- Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) TrialCirculation, 2002
- Effects of Sustained-Release Moxonidine, an Imidazoline Agonist, on Plasma Norepinephrine in Patients With Chronic Heart FailureCirculation, 2002
- The Regulation of Sympathetic Outflow in Heart FailureAnnals of the New York Academy of Sciences, 2001
- HMG-CoA Reductase Inhibitors: Is the Endothelium the Main Target?Cardiology, 2001
- Heart rate variability patterns before ventricular tachycardia onset in patients with an implantable cardioverter defibrillatorThe American Journal of Cardiology, 2000
- Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure- and cholesterol-lowering effectsKidney International, 2000
- Follow-up study of patients randomized in the scandinavian simvastatin survival study (4S) of cholesterol loweringThe American Journal of Cardiology, 2000
- Neuroprotection mediated by changes in the endothelial actin cytoskeletonJournal of Clinical Investigation, 2000
- Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.Journal of Clinical Investigation, 1998
- Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamineLife Sciences, 1977