Effects of inhibitors of tumor promotion on 12-O-tetradecanoylphor-bol-13-acetate-induced keratin modification in mouse epidermis
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 3 (11) , 1311-1315
- https://doi.org/10.1093/carcin/3.11.1311
Abstract
In order to investigate the role that hyperplasia plays in the induction of the keratin modifications by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the effects of several inhibitors of tumor promotion and cycloheximide on the TPA-induced protein changes were studied. The anti-inflammatory steroid fluocinolone acetonide and cyclohex-imide, which prevent the induction of hyperplasia, were found to prevent the appearance of the TPA-induced keratin modifications. Retinoic add and tosylphenylalanylchloro-methyl ketone, which have minor influence on hyperplasia, were found to have essentially no effect on these protein changes. These results provided further evidence that the TPA-induced epidermal keratin changes were associated with the induction of hyperplasia by TPA and not necessarily related to promoting ability.This publication has 3 references indexed in Scilit:
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