THE CHEMOTHERAPY OF INTRACRANIAL INFECTIONS
- 9 October 1943
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 123 (6) , 330-332
- https://doi.org/10.1001/jama.1943.02840410012004
Abstract
The great promise of penicillin as an antibacterial agent has recently received wide publicity, even in the lay press. The discovery of its antibacterial activity by Fleming1in 1929 and the outstanding investigations of Chain, Florey and their co-workers2beginning in 1940 have been reviewed by Hobby, Meyer, Dawson and Chaffee3(who also contributed valuable observations of their own). A recent summary of early clinical observations in Great Britain has been published by the Floreys4and extensive investigation of the use of penicillin is being carried on in this country.5 The experimental study to be reported herein was undertaken as one of a series of investigations of the treatment of infections of the central nervous system and its coverings.6This report will be limited to consideration of the effects of penicillin in experimental staphylococcic meningitis. DEATH WITHIN 8 HRS. DEATH AFTER 24 HRS. DEATHKeywords
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