Effect of Glycerine on Toxicity of Isoniazid in Mice

Publisher Website
Google Scholar
Abstract
Toxic effect of Isoniazid (INH) in DBA mice has been reduced by solution in aqueous glycerine. A sub-lethal dose of 4 mg INH (200 mg/kg) in 35% by volume of glycerine was given orally 30 times within 36 days with a higher survival rate and fewer toxic manifestations than the same dose of INH dissolved in water. Doses of 6 or 8 mg INH lethal per se in aqueous solution gave 50% mortality after 7 intermittent (twice weekly) administrations when 35% or 50% glycerine solution respectively was employed as solvent. With larger amounts of INH the requisite amount of glycerine lay in the toxic range. Higher blood plasma levels of INH were obtained with the glycerine solutions than with aqueous solutions. In higher concentrations of glycerine there was apparently synergism with INH in the in vitro bacteriostatic action on 2 human strains of Mycobacterlum tuberculosis.