The role of free radicals and antioxidants: How do we know that they are working?
- 1 January 1995
- journal article
- review article
- Published by Taylor & Francis in Critical Reviews in Food Science and Nutrition
- Vol. 35 (1-2) , 21-39
- https://doi.org/10.1080/10408399509527683
Abstract
This review briefly discusses how free radicals are formed and the possible participation of free radicals in disease. The review describes the basic radical reactions and the types of products that are formed from the free‐radical reactions of cellular constituents. In many cases, in vivo free‐radical oxidation can be detected by measuring products that were derived from radical reactions. Since aerobic organisms generate oxygen‐containing free radicals during oxygen metabolism, they carry chemicals and enzymes that reduce the threat posed by these radicals. The more common sources of in vivo free radicals are described in the article as well as the methods used by cells to protect themselves from free‐radical damage. Generation of free radicals in vivo also may be the result of exposure to certain chemical agents present in the environment Many of these agents cause pathologic changes to the exposed tissues and organs by initiating free‐radical reactions.Keywords
This publication has 102 references indexed in Scilit:
- Increased levels of monohydroxy metabolites of arachidonic acid and linoleic acid in LDL and aorta from atherosclerotic rabbitsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. II. Uptake and cytotoxicity of ultraviolet-treated LDL on lymphoid cell linesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cell. I. Chemical modifications of ultraviolet-treated low-density lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
- Nitric oxide: A cytotoxic activated macrophage effector moleculeBiochemical and Biophysical Research Communications, 1988
- Reduced hepatic α-tocopherol content after long-term administration of ethanol to ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysisThe Journal of Pediatrics, 1986
- Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivoChemico-Biological Interactions, 1986
- Depression of biliary glutathione excretion by chronic ethanol feeding in the ratLife Sciences, 1984
- Depressed hepatic glutathione and increased diene conjugates in alcoholic liver diseaseDigestive Diseases and Sciences, 1983
- Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism , , , ,Biochemical and Biophysical Research Communications, 1980