In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867
Open Access
- 1 October 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (10) , 4351-4353
- https://doi.org/10.1128/aac.49.10.4351-4353.2005
Abstract
The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis . DA-7867 was the most active drug with an MIC 90 of 0.125 μg/ml, compared to the MIC 90 s of 4 μg/ml of garenoxacin and 2 μg/ml of linezolid.Keywords
This publication has 11 references indexed in Scilit:
- A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosisScience, 2005
- Mycobacterium tuberculosis DNA Gyrase: Interaction with Quinolones and Correlation with Antimycobacterial Drug ActivityAntimicrobial Agents and Chemotherapy, 2004
- In Vitro Activities of New Antimicrobials against Nocardia brasiliensisAntimicrobial Agents and Chemotherapy, 2004
- In Vitro Activities of DA-7867, a Novel Oxazolidinone, against Recent Clinical Isolates of Aerobic and Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 2004
- The TB epidemic from 1992 to 2002Tuberculosis, 2003
- The global situation of MDR-TBTuberculosis, 2003
- In Vitro Activities of Linezolid against Clinical Isolates of Mycobacterium tuberculosis That Are Susceptible or Resistant to First-Line Antituberculous DrugsAntimicrobial Agents and Chemotherapy, 2003
- In vitro activity of moxifloxacin, levofloxacin, gatifloxacin and linezolid against Mycobacterium tuberculosisInternational Journal of Antimicrobial Agents, 2002
- Activities of Several Novel Oxazolidinones against Mycobacterium tuberculosis in a Murine ModelAntimicrobial Agents and Chemotherapy, 1999
- Rapid, Low-Technology MIC Determination with Clinical Mycobacterium tuberculosis Isolates by Using the Microplate Alamar Blue AssayJournal of Clinical Microbiology, 1998