Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification
- 1 October 2005
- journal article
- research article
- Published by Elsevier in International Journal of Pharmaceutics
- Vol. 303 (1-2) , 8-19
- https://doi.org/10.1016/j.ijpharm.2005.06.017
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsPublished by Elsevier ,2003
- Quantitative determination of saquinavir from Caco-2 cell monolayers by HPLC-UVBiomedical Chromatography, 2003
- Functional Characterization of Monocarboxylic Acid, Large Neutral Amino Acid, Bile Acid and Peptide Transporters, and P-Glycoprotein in MDCK and Caco-2 CellsJournal of Pharmaceutical Sciences, 2002
- BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTERAnnual Review of Pharmacology and Toxicology, 1999
- MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability ScreeningJournal of Pharmaceutical Sciences, 1999
- Structure, Function, and Molecular Modeling Approaches to the Study of the Intestinal Dipeptide Transporter PepT1Journal of Pharmaceutical Sciences, 1998
- Direct Evidence for Peptide Transporter (PepT1)-Mediated Uptake of a Nonpeptide Prodrug, ValacyclovirBiochemical and Biophysical Research Communications, 1998
- The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.Journal of Clinical Investigation, 1998
- Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicityInternational Journal of Cancer, 1992
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976