Thin-Layer Chromatographic Method for the Quality Control of Dexamethasone and Betamethasone Tablets

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Abstract
A rapia, sensitive and specific metnoa for the assay and identincation of corticosteriods (dexamethasone and betamethasone) in tablet forms is described. The method involves a rapia single step extraction of the sterolas with extremely low volume of solvents (0.1 ml water + 0.4 ml ethanol) followed by identifiction and estimation by thin layer chromatography using the solvenc system choroform : methanol : water : 180 : 15 : 1, v/v). The sterolas extracted from the chromatogram by ethanol were assayed directly by measuring the extinotion of the extract at the respective adsorption maxima (around 240 nm). The resuts agree with those obtained by the BP, 1980 and IP, 1966 methods.

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