Replacing the Nucleobases in DNA with Designer Molecules
Top Cited Papers
- 26 July 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 35 (11) , 936-943
- https://doi.org/10.1021/ar000183u
Abstract
DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar−phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.Keywords
This publication has 44 references indexed in Scilit:
- Synthesis of Fluorobenzene and Benzimidazole Nucleic-Acid Analogues and Their Influence on Stability of RNA DuplexesHelvetica Chimica Acta, 2000
- A DNA pentaplex incorporating nucleobase quintetsProceedings of the National Academy of Sciences, 1999
- Sulphidic Mediterranean surface waters during Pliocene sapropel formationNature, 1999
- Solution structure of a DNA duplex containing a replicable difluorotoluene–adenine pairNature Structural & Molecular Biology, 1998
- DNA NANOTECHNOLOGY: Novel DNA ConstructionsAnnual Review of Biophysics, 1998
- Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNAJournal of the American Chemical Society, 1995
- Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidines and Purine NucleosidesThe Journal of Organic Chemistry, 1994
- The contribution of DNA single-stranded order to the thermodynamics of duplex formation.Proceedings of the National Academy of Sciences, 1991
- Principles of Nucleic Acid StructurePublished by Springer Nature ,1984
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesisTetrahedron Letters, 1981