Megatrials are subordinate to medical science

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References ↵ Sackett DL, Haynes RB, Tugwell P . Clinical epidemiology: a basic science for clinical medicine. Boston: Little, Brown, 1985. ↵ Rosenberg W, Donald A . Evidence based medicine: an approach to clinical problem solving. BMJ 1995; 310: 1122–6. (29 April.) ↵ Charlton BG . Practice guidelines and practical judgment: the role of mega-trials, meta-analysis and consensus. Br J Gen Pract 1994; 44: x290–1. ↵ Julian D . Trials and tribulations. Cardiovasc Res 1994; 28: 598–603. ↵ Charlton BG . Mega-trials: methodological issues and clinical implications. J R Coll Physicians Lond 1995; 29: 96–100.