Immune Hemolysis: Determination of Values for Optimal and Maximal Sensitization. Comparison in Several Hemolytic Systems

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Abstract
Methods are given for determination of the amount of serum required for optimal and maximal sensitization of a hemolytic system. Values were determined for each of 4 hemolytic systems which differ in amounts of C'' required for lysis. When amounts of serum required for optimal and maximal sensitization in each system were expressed in hemolytic units, a correlation was found between these values and C'' activity. This correlation indicated that certain general basic factors are involved in sensitization of the cell by antibody. Possible factors and their role in cell sensitization are discussed.
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