CHANGES IN BONES AND JOINTS OF UNDERFED MICE BEARING ANTERIOR HYPOPHYSEAL GRAFTS1

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Abstract
IN MICE and guinea pigs, transplants and extracts of anterior hypophysis promoted skeletal growth and development; they also increased the incidence and advanced the onset of degenerative joint disease, the active principle being the somatotrophin fraction (1–3). Since under the influence of STH food consumption is increased (4), and since on the other hand the development of osteoarthritis was retarded in underfed rats (2), it seemed of interest to determine, whether or not the skeletal effects of anterior hypophysis were related to increased food intake. For this purpose, anterior hypophyses were transplanted into underfed mice, and the changes occurring in the long bones and joints were studied.