TRANSFER OF RADIOACTIVE HEME AND FORMATION OF HEMOGLOBIN

Abstract
Upon incubating (pH 7.4,37[degree]C,4 hr.) a mixture of the supernatant of hemolyzate, protoporphyrin, Fe59Cl3, and Fe-incorporating factor (the cholate extract of duck erythrocyte stroma) in the presence of cysteine, Fe59-heme-containing hemoglobin (Hb) was synthesized. Synthesized Hb is entirely dependent on the supernatant of hemolyzates of the respective species, as characterized by Amber-lite IRC 50 column chromatography. A heme-acceptor of a globin nature contained in the supernatant is probably participating.

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