Response of Adrenals, Thymus, Spleen and Leucocytes to Shuttle Box and Confinement Stress.

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Abstract
Influence of daily exposure to shuttle box and confinement stress on adrenal, thymus, spleen and leucocytes was determined in 4 to 6-week-old female Swiss mice. Cortical hypertrophy of the adrenal, leucopenia and involution of the thymus and spleen were consistently observed. Adrenal hypertrophy and drops in circulating leucocytes were rapid with significant changes observed following 3 to 7 days of stress. Involution of thymus and spleen occurred more slowly over a period of 14 to 28 days. Differences returned to non-significant levels within 3 weeks following termination of stress.