Rabbit liver enzymes responsible for reduction of nitropolycyclic aromatic hydrocarbons.
- 1 January 1983
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 31 (2) , 776-779
- https://doi.org/10.1248/cpb.31.776
Abstract
The present paper is the first description of mammalian nitroreductases acting upon nitropolycyclic aromatic hydrocarbons. Rabbit liver microsomal and cytosolic fractions have ability to reduce 1-nitropyrene or 2-nitrofluorene to the corresponding amine under anaerobic conditions. The nitroreductase activity in the former fraction is mainly due to a cytochrome P-450 system and that in the latter fraction is due to aldehyde oxidase.Keywords
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