Neuronal and Glial Somal Size in the Prefrontal Cortex
Open Access
- 1 March 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 55 (3) , 215-224
- https://doi.org/10.1001/archpsyc.55.3.215
Abstract
CONSIDERABLE evidence indicates that the prefrontal cortex of schizophrenic patients is subject to a pathological process, but the nature of this process is far from clear. Morphometric studies of prefrontal cortex in schizophrenic brains undertaken to date have generally focused on estimates of neuronal density and number.1-3 Although evaluation of neuronal cell size provides a measure of the structural integrity and viability of neuronal populations, only 1 study of neuronal size in the prefrontal cortex (Brodmann area 10) has been undertaken previously, and no size differences were observed between schizophrenic and control brains.3 In regions of the schizophrenic brain outside the prefrontal cortex, decreased neuronal size has been reported for pyramidal neurons in the hippocampus,4,5 substantia nigra,6 and locus ceruleus.7Keywords
This publication has 1 reference indexed in Scilit:
- Implications of Normal Brain Development for the Pathogenesis of SchizophreniaArchives of General Psychiatry, 1987