The X‐ray structure of a tetrapeptide bound to the active site of human cyclophilin A
- 6 April 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 300 (3) , 286-290
- https://doi.org/10.1016/0014-5793(92)80865-e
Abstract
Human cyclophilin A (165 residues) has peptidyl-prolyl cis-trans isomerase activity. Here we report a high-resolution three-dimensional X-ray structure of a substrate, ac-Ala-Ala-Pro-Ala-amc (ac. acetyl: amc. amidomethylcoumarin) bound to the active-site of cyclophilin. The structure consisting of a dimer of complexes and 135 water molecules was refined to a crystallographic R-factor of 17.7% for all data in the range 8 Å-2.3 Å.Keywords
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