Effect of Magnesium Sulfate on the Development of Cystic Periventricular Leukomalacia in Preterm Infants
- 1 May 1997
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in American Journal of Perinatology
- Vol. 14 (05) , 303-307
- https://doi.org/10.1055/s-2007-994149
Abstract
To determine if magnesium sulfate has an effect on the development of cystic periventricular leukomalacia in preterm infants, this retrospective case control study was conducted. There were 23,382 infants born at three teaching hospitals in the metropolitan New York area from January 1992 to December 1994. Four hundred ninety-two infants met our entrance criteria. Criteria included a birth weight p = 0.035) (OR = 0.196, 95% Cl = 0.039-0.988). Pre-eclampsia as an independent factor was not associated with a reduced risk (p = 0.251) (OR = 0.294, 95% Cl = 0.033-2.65). Preterm infants exposed to antenatal magnesium sulfate were found to have a reduced risk of developing cystic periventricular leukomalacia.Keywords
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