DNA polymorphism of the human complement component C7 gene in familial deficiencies
- 1 July 1990
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 85 (2) , 251-252
- https://doi.org/10.1007/bf00193207
Abstract
A C7 cDNA probe detecting a TaqI restriction fragment length polymorphism has been used to examine the segregation of the “silent allele” (C7*Q0) in two familial deficiencies. Carrier diagnosis in healthy children is possible when both parents are heterozygotes. Only one of these two families was informative. The “silent allele” is linked to different TaqI alleles in both families. This suggests that at least two different C7*Q0 alleles are present in our population. This paper gives a protocol for genetic studies of hereditary traits in which the C7 gene and other genes tightly linked to it are involved.Keywords
This publication has 5 references indexed in Scilit:
- The structure of human complement component C7 and the C5b-7 complex.Journal of Biological Chemistry, 1988
- A simple salting out procedure for extracting DNA from human nucleated cellsNucleic Acids Research, 1988
- Three Japanese Families with Members Carrying C7 Silent Allele (C7*Q0)Human Heredity, 1988
- FAMILY STUDY ON THE POLYMORPHISMS OF THE 6TH AND 7TH COMPONENTS (C6 AND C7) OF HUMAN-COMPLEMENT - LINKAGE AND HAPLOTYPE ANALYSES1986
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983