[Seminal fluid concentration of ketoconazole and its effect on spermatozoa motility].

  • 1 February 1984
    • journal article
    • abstracts
    • Vol. 59  (3) , 173-4, 177
Abstract
The concentration of Ketoconazole in seminal fluid has been measured in 7 men. The average concentration of 150 ng/g in seminal fluid is much lower than in blood plasma, but for the treatment of candidiasis the concentration in seminal fluid may be too low. A 50-fold higher Ketoconazole-concentration did not disturb sperm motility in 24 men. Therefore there may be no danger for motility of sperms in genital tract of women, for the tested Ketoconazole-concentration was 3-fold higher than the blood serum concentration.

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