Biochemical characteristics of 130 recent isolates from Haemophilus influenzae meningitis

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Abstract
A total of 130 Haemophilus strains, comprising virtually all isolates from Danish and Norwegian cases of Haemophilus meningitis occurring in the period from Oct. 1975 through Sept. 1976, were examined by biochemical and serological means. All isolates were identified as H. influenzae and, except for 1 noncapsulated strain, possessed a capsule of serotype b. The vast majority of strains (93%) belonged to biotype I, which, in contrast to biotypes II and III, is rarely encountered as a commensal of the upper respiratory tract. This finding is a strong incentive for studies of possible additional virulence factors associated with biotype I organisms. The results are discussed in the light of North American reports, which suggested changes in the etiology of Haemophilus meningitis.

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