Melatonin Is Able to Influence Its Secretion in Humans: Description of a Phase-Response Curve

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Abstract
A single physiological dose of melatonin (20 µg for 3 h given intravenously at different times of the day (04.00–12.00, 16.00 and 20.00 h) was able to shift the endogenous plasma melatonin profile of healthy volunteers under entrained conditions according to a phase-response curve (PRC). ANOVA showed an effect of the time of administration on the onset, the acrophase or the offset of the melatonin profiles. These profiles were significantly delayed when the infusion was administered at 12.00 h and advanced when the infusion was given at 20.00 h. Further, the AUCs evaluated on the nocturnal melatonin profiles were increased after the 04.00 h infusion (+20.5%, p

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