Remission induction in acute nonlymphocytic leukemia: Comparison of a seven‐day and ten‐day infusion of cytosine arabinoside in combination with adriamycin

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Abstract
Forty‐six previously untreated patients with acute nonlymphocytic leukemia were treated with a remission induction regimen consisting of three daily doses of Adriamycin (30 mg/m2/day) and a ten‐day continuous infusion of cytosine ara binoside (ara C) (100 mg/m2/day). The overall remission rate was 72%, with 88% of the patients < 50 and 62% of patients > 50 years old achieving complete remission status. Thirty‐one of the 33 complete remissions occurred after a single course of chemotherapy. Retrospective comparison of this regimen with its predecessor (identical, except that a seven‐day infusion of ara C was administered) demonstrated that the increase in duration of ara C administration resulted in greater antileukemic effectiveness without an increase in hematologic toxicity to the patient.