s-Triazolopyrazines

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Abstract
Earlier work on the preparation of 3-amino-s-triazolo[4,3-a]pyrazines has been extended to include further examples carrying alkyl substituents on the pyrazine ring, as well as compounds with hydrogen, hydroxy- or mercapto-groups in the 3-position. Acylation of the 3-amino-group has been shown to occur normally, although under certain conditions the triazole ring nitrogen is involved. The 3-amino-group is usually introduced by the action of cyanogen chloride on the related 2-hydrazinopyrazine in the presence of an aqueous acetate buffer. In one instance, the 3-acetamido-derivative was the main product isolated.

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