Elevated platelet membrane phosphatidylinositol-4,5-bisphosphate in bipolar mania
- 1 August 1993
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 150 (8) , 1252-1254
- https://doi.org/10.1176/ajp.150.8.1252
Abstract
Membrane phospholipids were measured in platelets of seven medication-free patients in the manic phase of bipolar affective disorder and seven healthy comparison subjects. The relative percentage of platelet membrane phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic patients than in the comparison subjects. These results are consistent with an enhanced neuronal second messenger response after 5-hydroxytryptamine receptor stimulation followed by neurotransmitter release.Keywords
This publication has 9 references indexed in Scilit:
- The calcium second messenger system in bipolar disorders: data supporting new research directionsThe Journal of Neuropsychiatry and Clinical Neurosciences, 1992
- Mania induced by fluoxetine in an adolescent patientAmerican Journal of Psychiatry, 1991
- The Family of Protein Kinase C for Signal TransductionPublished by American Medical Association (AMA) ,1989
- Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithiumAmerican Journal of Psychiatry, 1989
- Increased Platelet Intracellular Calcium Concentration in Patients With Bipolar Affective DisordersArchives of General Psychiatry, 1989
- Lithium Carbonate Treatment of ManiaArchives of General Psychiatry, 1987
- The Bech‐Rafaelsen Mania Scale and the Hamilton Depression ScaleActa Psychiatrica Scandinavica, 1979
- Research Diagnostic CriteriaArchives of General Psychiatry, 1978
- Requirement of Thymus-dependent Lymphocytes for Potentiation by Adjuvants of Antibody FormationNature, 1971