Bcl-2 expression correlates with apoptosis induction but not loss of clonogenic survival in small cell lung cancer cell lines treated with etoposide

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Abstract
The influence of bcl-2 oncogene expression on etoposide- Induced apoptosis and clonogenic survival was investigated In five small cell lung cancer (SCLC) cell lines, three of which were bcf-2-expressing and two of which were non-bcf-2- expressing. The bcf-2-expressing lines displayed a lower apoptosis propensity than the non-bcf-2-expresslng lines. When bcf-2-expressing cells were incubated in cystine/ methionine-free (CMF) medium, etoposide-induced apoptosis was restored to levels comparable to those seen in nonbcf- 2-expressing lines. However, the endpoint of clonogenic survival after drug treatment did not display any consistent pattern that correlated with bcf-2 status. In addition, treatment of the two bcf-2-expressing cell lines with etoposide in CMF medium did not modify their clonogenic survival curves compared to treatment in regular medium. These results are consistent with the idea that bcf-2 expression modulates etoposide-induced apoptosis but not clonogenic survival. [© 1998 Lippincott Williams & Wllkins.]
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