COMPARATIVE-STUDY OF ALTERATIONS IN CONCENTRATION OF FREE CHOLESTEROL AND IN ANTIOXIDATIVE ACTIVITY OF LIPID FRACTION FROM ANIMAL TISSUE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 22  (3) , 329-334
Abstract
An inverse correlation was observed between the alterations in concentration of free cholesterol and an antioxidative activity of lipids in several tissues and cells. The effect was studied in mouse liver tissue during reparative regeneration after partial hepatectomy, in intact mice liver under the directed action on the system of free radical cell lipid oxidation reactions and in a culture of HeLa cells [human cervical carcinoma] during various periods of cell cycle. Using the thermal oxidation of oleic acid methyl ester as a model system, cholesterol was found to function as a substrate in the reactions of free-radical cooxidation, and the products of oxidation of cholesterol were active as antioxidants. The significance of a system containing cholesterol and its oxidizing products is discussed in connection with the metabolism of cholesterol itself and in reactions related to alteration in free-radical oxidation of cell lipids.

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