Parasitologic Surveys in Cali, Departamento Del Valle, Colombia. IV. Experimental Study in Guinea Pigs of the Pathogenic Capacity of Entamoeba histolytica from Infected Persons in Ward Siloe, Cali

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Abstract
Fourteen strains of Entamoeba histolytica from essentially asymptomatic human infections were employed to test their pathogenic potential in young guinea pigs. Cysts of 6 strains were introduced per os into 38 animals and trophozoites cultured from 10 strains were inoculated intracecally into 115 animals. In the former group of tests 19.4% colonization and 2.6% or 5.2% tissue invasion were demonstrated; in the latter group, the comparable percentages were 62.1% and 51.4% respectively. Tissue invasion varied in degree from initial microscopic mucosal erosion, with single or multiple sites of invasion, to deep, fulminating and coalescing ulceration, usually confined to the cecum but once also involving the-adjacent colon and twice the terminal ileum. Although these strains of E histolytica, all but 1 exclusively or primarily of the large race, were obtained from essentially asymptomatic human carriers, the study demonstrated the relatively high pathogenic potential of the amebas to invade the cecal wall of guinea pigs.
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