Synthesis and Biological Activity of Four Adrenocorticotropin‐(1‐24)‐tetracosapeptide Analogues with N‐Terminal Deletions of Four to Seven Amino‐Acid Residues
- 19 April 1978
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 61 (3) , 1186-1192
- https://doi.org/10.1002/hlca.19780610334
Abstract
The syntheses of adrenocorticotropin‐(5–24)‐eicosapeptide, ‐(6–24)‐nonadecapeptide, ‐(7–24)‐octadecapeptide, and ‐(8–24)‐heptadecapeptide are described. Their biological activities on isolated adrenal cortex cells and adipocytes, on superfused adrenal tissue, as well as on the adenylate cyclase system of isolated cell membranes are summarized.Keywords
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