Antigrowth Effect of Some Inhibitors of Polyamine Synthesis on Transplantable Prostate Cancer
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 40 (1) , 57-62
- https://doi.org/10.1159/000225692
Abstract
Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer [in rats]. Inhibition of ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) or .alpha.-difluoromethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect. The combination of DFMO with MGBG was not only more effective but no more toxic than MGBG alone. Combination of MGBG with 9-B-D-arabinofuranosyladenine, an indirect effector of SAMDC, failed to increase therapeutic effectiveness of MGBG.Keywords
This publication has 10 references indexed in Scilit:
- Aminoguanidine reversal of the inhibitory effects of ornithine analogs on the in vitro clonogenic survival of the R3327 AT prostate-derived tumorCancer Letters, 1981
- Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis ; Effects of α-difluoromethyl- ornithine, an irreversible inhibitor or ornithine decarboxylaseLife Sciences, 1980
- High-performance liquid chromatographic determination of free and total polyamines in human serum as fluorescamine derivativesJournal of Chromatography B: Biomedical Sciences and Applications, 1979
- ALTERED POLYAMINES AND PEPTIDE-HORMONES (FSH, TSH, PROLACTIN, C-PEPTIDE) IN PROSTATIC HYPERPLASIA AND KIDNEY TUMORS1979
- RAT PROSTATIC ADENOCARCINOMA AS A MODEL FOR THE HUMAN-DISEASE1979
- EFFECT OF ALPHA-DIFLUOROMETHYLORNITHINE, AN ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE, ON L1210 LEUKEMIA IN MICE1978
- INCREASE OF URINARY PUTRESCINE IN 3,4-BENZOPYRENE CARCINOGENESIS AND ITS INHIBITION BY PUTRESCINE1978
- ALTERED POLYAMINE PROFILES IN PROSTATIC HYPERPLASIA AND IN KIDNEY TUMORS1978
- Chemotherapy of the Transplantable Adenocarcinoma (R-3327) of the Copenhagen RatOncology, 1977
- ENHANCEMENT OF ANTITUMOR ACTIVITY OF ARABINOFURANOSYLADENINE BY 2'-DEOXYCOFORMYCIN1976