Parallel Synthesis of Glycomimetic Libraries: Targeting a C-Type Lectin
- 8 April 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (9) , 1407-1410
- https://doi.org/10.1021/ol0340383
Abstract
We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of α-methyl mannopyranoside were identified.Keywords
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