Microlocalization of Photofrin in neoplastic lesions

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Abstract
Three tumor models were used to study the microlocalization of two photosensitizers, Photofrin and TPPS4 (mesotetra[p-sulphophenyl]porphyne). The three tumor types employed were subcutaneously and intramuscularly grown murine Lewis lung carcinoma, and lung micrometastases, grown on the same animal. The objective of the study was to determine whether these photosensitizers localize differently in these three tumor types. Common to all the tumors was the observation that no substantial photosensitizer fluorescence could be found in the tumor parenchyma. With Photofrin, most of the drug fluorescence was found in the periphery of the tumors, especially around blood vessels and possibly in some macrophages. On the other hand with TPPS4, most of the fluorescence was seen in the basement membrane of blood vessels and airways. The photosensitizer TPPS4 may therefore accumulate less specifically in tumor microenvironment than Photofrin. Both photosensitizers were also found to localize in necrotic areas.
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