Down’s Syndrome and Acute Megakaryoblastic Leukaemia

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Abstract
A case is reported of a child with Down's syndrome who developed acute megakaryoblastic leukaemia, and in whom the evolution of the disease was accompanied by increasing cytogenetic abnormalities. A review of the literature suggests that the presence of an abnormal chromosome 21 may predispose to the development of this type of leukaemia.

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