Independent Correlation Between Plasma Lipoprotein(a) and Angiographie Coronary Artery Disease in NIDDM

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Abstract
OBJECTIVE To examine the correlation between angiographie coronary artery disease (CAD) and plasma lipoprotein(a) [Lp(a)] concentration in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS In this cross-sectional study of 36 patients with NIDDM who underwent coronary angiography, CAD was assessed visually using a coronary artery score (CAS), and plasma Lp(a) was measured immunotur-bidimetrically. RESULTS Lp(a) concentration was significantly higher in patients in the middle and upper tenues of CASs (>4) compared with those in the lower tenue (≤4); geometric mean 0.30 g/l(95% confidence interval [CI] 0.22–0.40) vs. 0.12 g/l (0.08–0.17, P = 0.002). Lp(a) was significantly and positively correlated with the CAS (R2 23%, P = 0.006), independent of other cardiovascular risk factors, including lipoprotein related variables and glycated hemoglobin. CONCLUSIONS Plasma Lp(a) is a strong and independent correlate of the extent of angiographie CAD in symptomatic patients with NIDDM.

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