EFFECT OF THYROIDECTOMY AND THYROXINE ON THE MUCOPOLYSACCHARIDES OF WOUNDS AND SKIN

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Abstract
The incorporation of 35S sulphate and the total content of hexosamine in skin wounds was determined in thyroidectomized, normal, and thyroxine-treated guinea pigs. Seven days after the production of the wounds, all three groups showed an increase in the 35S incorporation and in the hexosamine content as compared with normal skin. While the relative incorporation of 35S sulphate was most intense among thyroidectomized guinea pigs, the three groups showed no difference in the content of hexosamine. Thyroidectomy induced a more rapid synthesis of sulphated mucopolysaccharide than that observed in the thyroxine-treated and control guinea pigs, whereas the total content of acid mucopolysaccharides in the wound tissues was not affected by either thyroidectomy or thyroxine.

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