Ebselen Reduces Cytochrome c Release From Mitochondria and Subsequent DNA Fragmentation After Transient Focal Cerebral Ischemia in Mice
- 1 August 2001
- journal article
- other
- Published by Wolters Kluwer Health in Stroke
- Vol. 32 (8) , 1906-1911
- https://doi.org/10.1161/01.str.32.8.1906
Abstract
Background and Purpose— The seleno-organic compound ebselen has both antioxidant and anti-inflammatory properties. Although ebselen has been shown to protect the brain against stroke, it is unclear...Keywords
This publication has 32 references indexed in Scilit:
- Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?Trends in Neurosciences, 1999
- Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in MiceJournal of Neuroscience, 1999
- Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral IschemiaJournal of Neuroscience, 1998
- Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damageMolecular Brain Research, 1998
- Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase DeficiencyJournal of Neuroscience, 1998
- Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal deathNeuron, 1995
- Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neuronsNeuroReport, 1994
- Oxidative Stress, Glutamate, and Neurodegenerative DisordersScience, 1993
- Reactive Oxygen Species and the Central Nervous SystemJournal of Neurochemistry, 1992
- Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.Proceedings of the National Academy of Sciences, 1991