GASTRIC SECRETION. III. THE ABSORPTION OF HEAVY WATER FROM POUCHES OF THE BODY AND ANTRUM OF THE STOMACH OF THE DOG

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Abstract
The exchange of water across the gastric membrane was investigated in the dog by observing the absorption of deuterium oxide (D2O), from stomach pouches. One animal had a pouch of the body, or acid secreting portion of the stomach, and another a pouch of the gastric antrum. Under the conditions of the expts., half of the D2O was absorbed in approx. 20 mins. There was no significant difference in the rate of absorption between the body and antral pouches. Whether the body pouch was in a secreting or resting state also made no difference. If it is assumed that the gastric membrane handles D2O as it does H2O, it can lie concluded that there is a rapid exchange of H2O between the gastric contents and body fluids; such an exchange would be a major reason for their isotonicity.

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