A Suitable Preparation for Pharmacological Analysis of EEG "Activation".

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Abstract
A suitable method is described for obtaining a reliable deafferented preparation with intact brain stem in the un -anesthetized non-curarized cat. The resting eeg pattern was well "deactivated" and suited to the analysis of adrenergic and cholinergic components of the "reticular activating system", free from extraneous pharmacological influences. Preliminary observations with relatively low doses (0.25-1 ;[mu].g/kg) of both adrenergic and cholinergic agents have suggested that a complete temporal independence could be demonstrated between the desynchronizing actions and the peripheral vascular effects of "activating" agents, introduced directly into the central nervous system by intra-innominate administration. Advantages of this preparation over those commonly used for drug-induced eeg activation were discussed.