Cytogenetic Evidence for a Clonal Involvement of Granulocyte-Macrophage and Erythroid Lineages in a Patient with Refractory Anaemia

1 January 1988

journal article
research article
Published by S. Karger AG in Acta Haematologica

Vol. 80 (2) , 110-115
https://doi.org/10.1159/000205614

Abstract

To investigate the clonal origin of refractory anaemia, we carried out cytogenetic studies on single haematopoietic colonies derived from granulocyte-macrophage precursors (CFU-GM) and erythroid precursors (BFU-E). Marrow cells from a patient with refractory anaemia revealed the coexistence of a normal and an abnormal karyotype; 46, XY/45, XY,-15,-18, + der(15ql8q). Cytogenetic studies on CFU-GM- and BFU-E-derived colonies obtained from the bone marrow showed the presence of the same karyotypic abnormality carrying the der(15ql8q). Colonies carrying a normal diploid karyotype were also detected in the same culture dish. These results indicate that the clone with the der(15ql8q) chromosome abnormality arises in a stem cell which can differentiate to at least both granulocyte-macrophage and erythroid lineages.

Keywords

This publication has 1 reference indexed in Scilit:

Human Preleukemia
Annals of Internal Medicine, 1980