Measurement of thiamylal and thiopental in plasma by electron capture and flame photometric gas-liquid chromatography.
- 1 July 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 23 (7) , 1306-1309
- https://doi.org/10.1093/clinchem/23.7.1306
Abstract
We describe an isothermal gas-liquid chromatographic procedure developed for measuring thiamylal and thiopental in plasma. The unchanged drug is extracted into ethyl acetate from acidified plasma, together with an internal standard. The solvent is removed, the residue methylated, aliquots, diluted with benzene, are injected into a 183-cm gas-liquid chromatographic column containing 3% OV-17. Sensitivity of detection is in the nanogram to picogram range.This publication has 0 references indexed in Scilit: