Iminomalonate as a Convenient Electrophilic Amination Reagent for Grignard Reagents
- 1 August 2002
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 75 (8) , 1819-1825
- https://doi.org/10.1246/bcsj.75.1819
Abstract
Diethyl 2-[N-(p-methoxyphenyl)imino]malonate underwent amination reactions with alkyl Grignard reagents to give N-aklylation products in good yields. The obtained N-alkylation products were readily converted into N-alkyl-p-anisidines by the oxidative removal of the malonate moiety. The p-methoxyphenyl group was subsequently deprotected to give primary amines.This publication has 38 references indexed in Scilit:
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