Dopamine synthesis in rat striatum: Mobilization of tyrosine from non-dopaminergic cells
- 1 October 1987
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 43 (10) , 1109-1110
- https://doi.org/10.1007/bf01956051
Abstract
Unilateral nigrostriatal lesions in rats that almost totally depleted striatal dopamine had no effect on striatal levels of dopamine's precursor, tyrosine, nor on those of leucine. Since prolonged electrical stimulation of the slices markedly depletes them of tyrosine (1, 2) we conclude that tyrosine can be mobilized from non-dopaminergic striatal cells to augment dopamine release.Keywords
This publication has 4 references indexed in Scilit:
- Catecholamine synthesis: Physiological coupling to precursor supplyBiochemical Pharmacology, 1986
- Tyrosine availability determines stimulus-evoked dopamine release from rat striatal slicesNeuroscience Letters, 1985
- Rapid measurement of free amino acids in serum and CSF using high-performance liquid chromatographyLife Sciences, 1981
- Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmittersProgress in Neurobiology, 1979