Growth Inhibition of Prematures Receiving Tetracycline

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Abstract
Drugs and biologicals apparently safe for adults and children may have unusual and hazardous side-effects when transplacentally acquired by the fetus or administered to the premature and term infant. This report will document clinical and laboratory evidence of an unusual effect, in the fetus and premature infant, of the widely used antibiotic, tetracycline. Tetracycline is known to deposit as a fluorescent complex in growing bone. This effect has no known clinical import in the older child or adult; recent limited observations, however, suggest that in the fetus and newborn it may prove to be of clinical significance. Tetracycline Deposition and Fluorescence in Bone In 1957 Rall et al.1demonstrated that the tetracyclines (tetracycline, chlortetracycline, and oxytetracycline) localize in tumors and bone as a fluorescent complex. Further experimental and clinical evidence indicates2,3that, after a single dose of a tetracycline, its fluorophore accumulates and is retained in the soft

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