Antibody response in Lewis rats injected with myelin oligodendrocyte glycoprotein derived peptides

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Abstract
Previous studies from our laboratory have demonstrated a predominant response to myelin oligodendrocyte glycoprotein (MOG) in patient6s with multiple scleros(MS) and showed that this molecule is able to Induce in Lewis rats a chronic relapsingMS-like disease with extensive demyelination. To further study the possibility that MOG is a primary target antigen in MS, we have begun to Investigats the encephallilogenioity and antibody response of different sequences of the encompassing the MOG amino acid sequences 1-21,67-87,104-117 and 202-216 were encaphalltogentic. In contrast, a single injection of MOG35-55 was able to Induce severe neunogogical signs assiociated with inflemmation and demyelellnation. As indicated by the absence of reactivity to the other MOG peptides tested as well as other central nervous system mysalin proteins including myallin basic protein and protalaid protein, the antibody response produced by MOG pepticles is highly restricted.

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