Diamine-Catalyzed Asymmetric Michael Additions of Aldehydes and Ketones to Nitrostyrene
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- 12 September 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (21) , 3611-3614
- https://doi.org/10.1021/ol026543q
Abstract
The direct Michael addition of aldehydes and ketones to nitrostyrene, catalyzed by N-i-Pr-2,2‘-bipyrrolidine, is described. The desired 1,4-adducts are obtained in excellent yield with enantioselectivities up to 85% ee and dr up to 95:5 of the syn product.Keywords
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